Antagonistic interactions between gemcitabine and 5-fluorouracil in the human pancreatic carcinoma cell line capan-2
نویسندگان
چکیده
منابع مشابه
Gemcitabine and 5-Fluorouracil for Advanced Pancreatic Carcinoma
Pancreatic carcinoma is one of the most malignant tumors of alimentary system,and its incidence rate had a tendency to rise in the past decades (Hua et al., 2009; Tuli et al., 2012; Zhou et al., 2012). Early diagnosis of pancreatic carcinoma is still difficult, the majority patients with pancreatic carcinoma are in an advanced stage at the time of diagnosis (Ikeda et al.,2009; Klauss et al., 20...
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The nucleoside analogue gemcitabine displays therapeutic effects mainly against breast, ovarian and pancreatic cancer. Mucin, encoded by the gene MUC1, is a well-established tumor antigen expressed on these tumors. Knowledge of possible effects of chemotherapeutic drugs on the level of mucin epitope expression is important for the design of clinical protocols combining chemo- and immunotherapeu...
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Prior to their use in patients with hepatic metastasis of colon cancer, we studied the cell-killing effects of 5-fluorouracil, 5-fluoro-2'-deoxyuridine, 3',5'-dichloromethotrexate (DCM), and 5-fluoro-2'-deoxyuridine, 3',5'-dichloromethotrexate (DCM), and combinations of these fluoropyrimidines with DCM on a human colon carcinoma cell line (HCT-8). Sequential exposure of these cells to DCM follo...
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Pancreatic cancer (PC) is one of the most common cancers and has a poor prognosis due to late diagnosis and ineffective therapeutic multimodality. MicroRNAs (miRNAs, miRs) are a group of non-coding, small RNAs with active biological activities. In our investigation, human pancreatic cancer cell line Capan-2 were transfected with miR-222 mimics, inhibitors or their negative controls. Cell prolif...
متن کاملInteraction of gamma interferon and 5-fluorouracil in the H630 human colon carcinoma cell line.
The antiproliferative effects and pharmacological interactions of 5-fluorouracil (5-FU) in combination with gamma interferon (IFN-gamma) were determined against the human colon carcinoma H630 cell line in vitro. H630 was 9-fold more resistant to 5-FU, as compared to a relatively sensitive human colon line (C1). IFN-gamma showed modest antiproliferative activity against the H630 line, with a 50%...
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ژورنال
عنوان ژورنال: Cancer Biology & Therapy
سال: 2006
ISSN: 1538-4047,1555-8576
DOI: 10.4161/cbt.5.10.3152